The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

Ca2+ is a ubiquitous intracellular messenger responsible for controlling numerous cellular
processes including fertilization, mitosis, neuronal transmission, contraction and relaxation …

Increasing evidence supports an association between the skeleton and energy metabolism.
These interactions are mediated by a variety of hormones, cytokines and nutrients. Here, the …

Recent progress has been made in our understanding of the functional role of the seven-
transmembrane-spanning extracellular calcium-sensing receptor (CaSR) in bone cells. Both …

The discovery of a G protein–coupled, calcium-sensing receptor (CaR) a decade ago and of
diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical …

Calcium balance is essential for a multitude of physiological processes, ranging from cell
signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a …

Background GPRC6A is a widely expressed orphan G-protein coupled receptor that senses
extracellular amino acids, osteocalcin and divalent cations in vitro. The physiological …

The C family G-protein-coupled receptors contain members that sense amino acid and
extracellular cations, of which calcium-sensing receptor (CASR) is the prototypic …

Bone is the major sink and store for calcium and it fulfils essential roles in the maintenance
of extracellular free ionised calcium concentration ([Ca2+] e) within its homeostatic range …

Age‐related osteopenia is characterized by a negative balance between bone resorption
and formation. The anti‐osteoporotic drug strontium ranelate was found to reduce bone …