Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …

This perspective describes predictive processing as a computational framework for
understanding cortical function in the context of emerging evidence, with a focus on sensory …

INTRODUCTION In the absence of sensory inputs, the brain produces structured patterns of
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …

Predictive processing postulates the existence of prediction error neurons in cortex. Neurons
with both negative and positive prediction error response properties have been identified in …

Sensory, motor and cognitive operations involve the coordinated action of large neuronal
populations across multiple brain regions in both superficial and deep structures,. Existing …

Functions of the neocortex depend on its bidirectional communication with the thalamus, via
cortico-thalamo-cortical (CTC) loops. Recent work dissecting the synaptic connectivity in …

Cognition can be conceptualized as a set of algorithmic control functions whose real-time
deployment determines how an organism stores and uses information to guide thought and …

The human brain is a complex, adaptive system comprised of billions of cells with trillions of
connections. The interactions between the elements of the system oppose this seemingly …

Decisions take time, and as a rule more difficult decisions take more time. But this only
raises the question of what consumes the time. For decisions informed by a sequence of …

Pupillometry has long been used as a measure of brain state. Changes in pupil diameter are
thought to coincide with the activity of neuromodulators, including noradrenaline and …