Gene expression is in part controlled by cis-regulatory elements (CREs) such as enhancers
and repressive elements. Anecdotal evidence has indicated that a CRE and a promoter …

The mouse embryo is the canonical model for mammalian preimplantation development.
Recent advances in single cell profiling allow detailed analysis of embryogenesis in other …

Abstract Roundabout4 (Robo4) is a transmembrane receptor that belongs to the
Roundabout (Robo) family of axon guidance molecules. Robo4 is an endothelial-specific …

E26 transformation-specific (ETS) variant 4 (ETV4) is an important transcription factor that
belongs to the ETS transcription factor family and is essential for much cellular physiology …

How bipotential hepatoblasts differentiate into hepatocytes and cholangiocytes remains
unclear. Here, using single‐cell transcriptomic analysis of hepatoblasts, hepatocytes, and …

The gene regulatory network (GRN) of naive mouse embryonic stem cells (ESCs) must be
reconfigured to enable lineage commitment. TCF3 sanctions rewiring by suppressing …

Background EMT is an important biological process in the mechanism of tumor invasion and
metastasis. However, there are still many unknowns about the specific mechanism of EMT in …

Small cell lung cancer (SCLC) remains a lethal disease with a dismal overall survival rate of
6% despite promising responses to upfront combination chemotherapy. The key drivers of …

Purpose: Plexiform neurofibromas (PNF) are peripheral nerve sheath tumors that cause
significant morbidity in persons with neurofibromatosis type 1 (NF1), yet treatment options …

Cancer stem cells (CSCs) are a major cause of tumor treatment resistance, relapse and
metastasis. Cancer cells exhibit reprogrammed metabolism characterized by aerobic …