The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan
embryogenesis and a defining structural feature of organ development. Current interest in …

HER2 is highly expressed in a significant proportion of breast cancer, ovarian cancer, and
gastric cancer. Since the discovery of its role in tumorigenesis, HER2 has received great …

The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles
in regulating cell proliferation, survival, differentiation and migration. The ErbB receptors …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is
frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as …

This review article describes the pathways and mechanisms of endocytosis and post-
endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Mucins are heavily glycosylated high molecular weight glycoproteins, which are involved in
the protection and lubrication of luminal epithelial surfaces. Transmembrane mucins also …

The ErbB receptor tyrosine kinases evolved as key regulatory entities enabling the
extracellular milieu to communicate with the intracellular machinery to bring forth the …

The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of
biological processes from neuronal development to breast cancer. New information …