Fatty acid desaturases, polyunsaturated fatty acid regulation, and biotechnological advances

JM Lee, H Lee, SB Kang, WJ Park - Nutrients, 2016 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are considered to be critical nutrients to regulate human
health and development, and numerous fatty acid desaturases play key roles in synthesizing …

Metabolism and functions of lipids and fatty acids in teleost fish

DR Tocher - Reviews in fisheries science, 2003 - Taylor & Francis
Lipids and their constituent fatty acids are, along with proteins, the major organic
constituents of fish, and they play major roles as sources of metabolic energy for growth …

The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms

C Ratledge, JP Wynn - Advances in applied microbiology, 2002 - Elsevier
The concept of using microorganisms as sources of oils and fats has a long history. The
commercial opportunities of such processes have been continuously examined for nearly a …

Elongation of long-chain fatty acids.

AE Leonard, SL Pereira, H Sprecher, YS Huang - 2004 - cabidigitallibrary.org
Fatty acids are critical for the normal development and function of all organisms, and in
particular, very long chain PUFAs are necessary for the health and maintenance of higher …

Fatty acids from lipids of marine organisms: molecular biodiversity, roles as biomarkers, biologically active compounds, and economical aspects

JP Bergé, G Barnathan - Marine biotechnology I, 2005 - Springer
Because of their characteristic living environments, marine organisms produce a variety of
lipids. Fatty acids constitute the essential part of triglycerides and wax esters, which are the …

Cloning, expression, and fatty acid regulation of the human Δ-5 desaturase

HP Cho, M Nakamura, SD Clarke - Journal of Biological Chemistry, 1999 - ASBMB
Arachidonic (20: 4 (n-6)), eicosapentaenoic (20: 5 (n-3)), and docosahexaenoic (22: 6 (n-3))
acids are major components of brain and retina phospholipids, substrates for eicosanoid …

Production of recombinant proteins by filamentous fungi

OP Ward - Biotechnology advances, 2012 - Elsevier
The initial focus of recombinant protein production by filamentous fungi related to exploiting
the extraordinary extracellular enzyme synthesis and secretion machinery of industrial …

Biosynthesis and regulation of microbial polyunsaturated fatty acid production

M Certik, S Shimizu - Journal of bioscience and bioengineering, 1999 - Elsevier
Growing interest in polyunsaturated fatty acid (PUFA) applications in various fields coupled
with their significance in health and dietary requirements has focused attention on the …

Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants

B Qi, T Fraser, S Mugford, G Dobson, O Sayanova… - Nature …, 2004 - nature.com
We report the production of two very long chain polyunsaturated fatty acids, arachidonic acid
(AA) and eicosapentaenoic acid (EPA), in substantial quantities in a higher plant. This was …

A vertebrate fatty acid desaturase with Δ5 and Δ6 activities

N Hastings, M Agaba, DR Tocher… - Proceedings of the …, 2001 - National Acad Sciences
Δ5 and Δ6 fatty acid desaturases are critical enzymes in the pathways for the biosynthesis of
the polyunsaturated fatty acids arachidonic, eicosapentaenoic, and docosahexaenoic acids …