Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Chromatin profiling at locus resolution uncovers gene regulatory features that define cell
types and developmental trajectories, but it remains challenging to map and compare …

Technologies that profile chromatin modifications at single-cell resolution offer enormous
promise for functional genomic characterization, but the sparsity of the measurements and …

Highlights•Chromatin dynamics regulate pattern, timing and magnitude of gene
expression.•Signal transduction downstream of TLR4 regulate histones for inducible gene …

Chromatin states are functionally defined by a complex combination of histone
modifications, transcription factor binding, DNA accessibility and other factors. Current …

Chromatin profiling in single cells has been extremely challenging and almost exclusively
limited to histone proteins. In cases where single-cell methods have shown promise, many …

Genome regulation is governed by the dynamics of chromatin modifications. The extensive
and diverse array of DNA and histone modifications allow multiple elements to act …

Technological progress over the past 15 years has fueled an explosion in genome‐wide
chromatin profiling tools that take advantage of low‐cost short‐read sequencing …

With the development of ever more powerful and versatile high-throughput sequencing
techniques and innovative ways to capture single cells, mapping the multicellular tissues at …

Inflammatory bowel disease (IBD) is a multifactorial disease that is shaped by a combination
of genetic mutations, the epigenome, and environmental variables, including commensal …