Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides,
and load these peptides onto major histocompatibility complex (MHC) class I and II …

Objective Neutrophils are an important component of the inflammatory response that
characterizes acute lung injury (ALI). This discussion aims to review the contribution of …

Low molecular weight fragmentation products of the polysaccharide of Hyaluronic acid
(sHA) produced during inflammation have been shown to be potent activators of …

We have identified a subset of genes that is specifically induced by stimulation of TLR3 or
TLR4 but not by TLR2 or TLR9. Further gene expression analyses established that …

The functions of dendritic cells (DCs) are tightly regulated such that protective immune
responses are elicited and unwanted immune responses are prevented. 1α25 …

High mobility group box 1 (HMGB1) is an abundant and conserved nuclear protein that is
released by necrotic cells and acts in the extracellular environment as a primary …

Members of the phosphoinositide-3 kinase (PI3K) family control several cellular responses
including cell growth, survival, cytoskeletal remodeling and the trafficking of intracellular …

Gene targeting of the adaptor molecule DAP12 in mice caused abnormal distribution and
impaired antigen presentation capacity of dendritic cells (DCs). However, the DAP12 …

Luteolin, a plant flavonoid, has potent anti-inflammatory properties both in vitro and in vivo.
However, the molecular mechanism of luteolin-mediated immune modulation has not been …

Metastatic melanoma is the most aggressive and obstinate skin cancer with poor prognosis.
Variant novel applicable regimens have emerged during the past decades intensively, while …