The development of B cells is dependent on the sequential DNA rearrangement of
immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a …

The development and differentiation of T cells represents a long and highly coordinated, yet
flexible at some points, pathway, along which the sequential and dynamic expressions of …

In mammalian cells, the MYC oncoprotein binds to thousands of promoters,,,. During
mitogenic stimulation of primary lymphocytes, MYC promotes an increase in the expression …

MYC is implicated in the development and progression of pancreatic cancer, yet the precise
level of MYC deregulation required to contribute to tumor development has been difficult to …

T and B cells share a common somatic gene rearrangement mechanism for assembling the
genes that code for their antigen receptors; they also have developmental pathways with …

Transcription factors play important roles in lymphopoiesis. We have previously
demonstrated that Bcl11a is essential for normal lymphocyte development in the mouse …

Rapid advances in genomics have opened unprecedented possibilities to explore the
mutational landscapes in malignant diseases, such as B-cell acute lymphoblastic leukemia …

B-lymphocyte development in the bone marrow is controlled by the coordinated action of
transcription factors creating regulatory networks ensuring activation of the B-lymphoid …

During the last decades, many studies have investigated the transcriptional and epigenetic
regulation of lineage decision in the hematopoietic system. These efforts led to a model in …

Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that
influence cellular proliferation, differentiation, apoptosis, and/or senescence. Many gene …