Molecular mechanisms in autoimmune thyroid disease
H Vargas-Uricoechea - Cells, 2023 - mdpi.com
The most common cause of acquired thyroid dysfunction is autoimmune thyroid disease,
which is an organ-specific autoimmune disease with two presentation phenotypes …
which is an organ-specific autoimmune disease with two presentation phenotypes …
Three-dimensional genome organization in immune cell fate and function
S Cuartero, G Stik, R Stadhouders - Nature Reviews Immunology, 2023 - nature.com
Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …
transcriptional programmes. Three-dimensional (3D) organization of the genome has …
The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis
FoxP3 is an essential transcription factor (TF) for immunologic homeostasis, but how it
utilizes the common forkhead DNA-binding domain (DBD) to perform its unique function …
utilizes the common forkhead DNA-binding domain (DBD) to perform its unique function …
Mutations from patients with IPEX ported to mice reveal different patterns of FoxP3 and Treg dysfunction
Mutations of the transcription factor FoxP3 in patients with" IPEX"(immune dysregulation,
polyendocrinopathy, enteropathy, X-linked syndrome) disrupt regulatory T cells (Treg) …
polyendocrinopathy, enteropathy, X-linked syndrome) disrupt regulatory T cells (Treg) …
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central
role in regulating immune responses provided a deeper understanding of self-tolerance …
role in regulating immune responses provided a deeper understanding of self-tolerance …
Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity
K Ichiyama, J Long, Y Kobayashi, Y Horita, T Kinoshita… - Immunity, 2024 - cell.com
The master transcription factor of regulatory T (Treg) cells, forkhead box protein P3 (Foxp3),
controls Treg cell function by targeting certain genes for activation or repression, but the …
controls Treg cell function by targeting certain genes for activation or repression, but the …
FOXP3 recognizes microsatellites and bridges DNA through multimerization
FOXP3 is a transcription factor that is essential for the development of regulatory T cells, a
branch of T cells that suppress excessive inflammation and autoimmunity,,,–. However, the …
branch of T cells that suppress excessive inflammation and autoimmunity,,,–. However, the …
Genomic analysis of Foxp3 function in regulatory T cells
GA Dolsten, Y Pritykin - The Journal of Immunology, 2023 - journals.aai.org
Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing
autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor …
autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor …
Foxp3 orchestrates reorganization of chromatin architecture to establish regulatory T cell identity
Chromatin conformation reorganization is emerging as an important layer of regulation for
gene expression and lineage specification. Yet, how lineage-specific transcription factors …
gene expression and lineage specification. Yet, how lineage-specific transcription factors …
An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long‐range loop formation
X Li, S Zeng, L Chen, Y Zhang, X Li, B Zhang… - Cell …, 2024 - Wiley Online Library
Cebpa is a master transcription factor gene for adipogenesis. However, the mechanisms of
enhancer–promoter chromatin interactions controlling Cebpa transcriptional regulation …
enhancer–promoter chromatin interactions controlling Cebpa transcriptional regulation …