The epidermal growth factor receptor (EGFR) is a cell-surface receptor belonging to ErbB
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …

When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger
a rich network of signalling pathways, culminating in responses ranging from cell division to …

The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine
kinases (RTK). These trans-membrane proteins are activated following binding with peptide …

Cancer is the term used to describe over 100 diseases that share several common
hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the …

Overexpression of ErbB2, a receptor-like tyrosine kinase, is shared by several types of
human carcinomas. In breast tumors the extent of overexpression has a prognostic value …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family
that is abnormally activated in many epithelial tumors. Several mechanisms lead to the …

Publisher Summary This chapter focuses on the mechanisms of ligand-induced heterodimer
formation, and on signaling pathways employed by ErbB-2 and ErbB-3 in normal and …

While a large proportion of patients presenting with stage I and II squamous cell carcinoma
of the head and neck (SCCHN) will remain disease free after single modality treatment, the …

Head and neck squamous cell carcinomas (HNSCC) arising from the oral cavity, pharynx,
and larynx constitute the 6 th most common human cancer. Human papillomavirus (HPV) …

Epidermal growth factor receptor (EGFR) exists in the nucleus of highly proliferative cells
where it functions as a transcription factor. Although EGFR has transactivational activity, it …