Systemic autoimmune diseases are characterized by the failure of the immune system to
differentiate self from non-self. These conditions are associated with significant morbidity …

Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Infection caused by SARS-CoV-2 can result in severe respiratory complications and death.
Patients with a compromised immune system are expected to be more susceptible to a …

Neutrophils are polymorphonuclear leukocytes of the phagocytic system that act as first line
of host defense against invading pathogens but are also important mediators of …

Epigenetic pathways play a pivotal role in the development and function of the immune
system. Over the last decade, a growing body of studies has been published out seeking to …

Historically, systemic self-inflammatory conditions were classified as either autoinflammatory
and caused by the innate immune system or autoimmune and driven by adaptive immune …

Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …

Infections, cardiovascular disease, and cancer are major causes of disease and death
worldwide. Neutrophils are inescapably associated with each of these health concerns, by …

Abstract The Inflammatory Bowel Diseases (IBD), Ulcerative Colitis (UC) and Crohn's
Disease (CD) are characterised by chronic non-resolving gut mucosal inflammation …

Neutrophil dysregulation is implicated in the pathogenesis of systemic lupus erythematosus
(SLE). SLE is characterized by elevated levels of a pathogenic neutrophil subset known as …