Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …

Polyamines are ubiquitous and essential components of mammalian cells. They have
multiple functions including critical roles in nucleic acid and protein synthesis, gene …

Polycationic polyamines are present in nearly all living organisms and are essential for
mammalian cell growth and survival, and for development. These positively charged …

Polyamines (PAs) have been considered as important molecules for survival. However,
evidence reinforces that PAs are also implicated, directly or indirectly, in pathways …

Spermidine is a naturally occurring endogenous polyamine synthesized from diamine
putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal …

Alzheimer’s disease as a chronic maladaptive polyamine stress response - PMC Back to Top
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The polyamines spermidine and spermine are positively charged aliphatic molecules. They
are critical in the regulation of nucleic acid and protein structures, protein synthesis, protein …

In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including
spermine, spermidine and putrescine, are involved in many cellular processes. Spermine …

Accumulating evidence indicate that astrocytes are essential players of the excitatory and
inhibitory signaling during normal and epileptiform activity via uptake and release of …

Polyamine oxidation plays a major role in neurodegenerative diseases. Previous studies
from our laboratory demonstrated that spermine oxidase (SMOX, a member of the polyamine …