Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as
phytic acid or IP6, with their biological activities received much attention for their role in …

Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …

The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-
InsPs) is a daunting challenge due to the large number of possible isomers, the absence of …

In plants, phosphate (P i) homeostasis is regulated by the interaction of PHR transcription
factors with stand-alone SPX proteins, which act as sensors for inositol pyrophosphates. In …

Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …

OBJECTIVE: Inositol is a carbocyclic sugar polyalcohol. By epimerization of its hydroxyl
groups, nine possible stereoisomers can be generated, two of major physiological and …

Phosphorylation is the most common module of cellular signalling pathways. The dynamic
nature of phosphorylation, which is conferred by the balancing acts of kinases and …

All cells rely on nutrients to supply energy and carbon building blocks to support cellular
processes. Over time, eukaryotes have developed increasingly complex systems to integrate …

Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which
regulate central biological processes in health and disease, such as cellular phosphate and …

The lack of effective vaccines and the development of resistance to the current treatments
highlight the urgent need for new anti-leishmanials. Sphingolipid metabolism has been …