Even after a century of investigation, our understanding of how enzymes work remains far
from complete. In particular, several factors that enable enzymes to achieve high catalytic …

Inhibitors of dihydrofolate reductase (DHFR), an enzyme that catalyzes 5, 6, 7, 8-
tetrahydrofolate synthesis, have been used as antimicrobial as well as antimetabolite drugs …

Plasmid-encoded R67 dihydrofolate reductase (DHFR) catalyzes a hydride transfer reaction
between substrate dihydrofolate (DHF) and its cofactor, nicotinamide adenine dinucleotide …

Type II R67 dihydrofolate reductase (DHFR) is a bacterial plasmid‐encoded enzyme that is
intrinsically resistant to the widely‐administered antibiotic trimethoprim. R67 DHFR is …

Objectives Enzyme dihydro foliate reductase (DHFR) is involved in synthesis of DNA and
consequently, has long been recognized to have utmost therapeutic significance, since its …

Previous osmotic pressure studies of two nonhomologous dihydrofolate reductase (DHFR)
enzymes found tighter binding of the nicotinamide adenine dinucleotide phosphate cofactor …

Homotetrameric R67 dihydrofolate reductase possesses 222 symmetry and a single active
site pore. This situation results in a promiscuous binding site that accommodates either the …

Tuberculosis, caused by Mycobacterium tuberculosis, is an infectious disease with high
levels of mortality worldwide, currently with approximately 6.3 million new cases per year …

There is lot of interest in the folate metabolism because of the essential role of folate
coenzymes in nucleic acid synthesis. Gamma (γ) radiation is well known for inducing …

Urinary Tract Infection is a frequent problem worldwide which is caused by microbial
invasion into the different tissues of the urinary tract. Although antibiotics are the first …