The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

Colorectal liver metastasis: molecular mechanism and interventional therapy

H Zhou, Z Liu, Y Wang, X Wen, EH Amador… - Signal transduction and …, 2022 - nature.com
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

Mechanisms of metastasis in colorectal cancer and metastatic organotropism: hematogenous versus peritoneal spread

E Pretzsch, F Bösch, J Neumann… - Journal of …, 2019 - Wiley Online Library
Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The
most common sites of metastasis are the liver and the peritoneum. Peritoneal …

Oncogenic roles of EMT-inducing transcription factors

A Puisieux, T Brabletz, J Caramel - Nature cell biology, 2014 - nature.com
The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …

Epithelial–mesenchymal transition in colorectal cancer metastasis: a system review

H Cao, E Xu, H Liu, L Wan, M Lai - Pathology-Research and Practice, 2015 - Elsevier
Tumor metastasis is a multi-step process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. And metastasis is the major cause of death …

Glucose metabolism on tumor plasticity, diagnosis, and treatment

X Lin, Z Xiao, T Chen, SH Liang, H Guo - Frontiers in oncology, 2020 - frontiersin.org
Malignant cells support tumor proliferation and progression by adopting to metabolic
changes. Tumor cells altered metabolism by increasing glucose uptake and fermentation of …

Epithelial–mesenchymal transition in human cancer: comprehensive reprogramming of metabolism, epigenetics, and differentiation

L Li, W Li - Pharmacology & therapeutics, 2015 - Elsevier
The epithelial–mesenchymal transition (EMT) is a developmental process that is important
for embryogenesis, wound healing, organ fibrosis, and cancer metastasis. Cancer …

Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung …

K Yang, W Zhang, L Zhong, Y Xiao, S Sahoo… - Cell Death & …, 2023 - nature.com
Lung cancer is the leading cause of cancer-related deaths worldwide. KRAS is the main
oncogenic driver in lung cancer that can be activated by gene mutation or amplification, but …

MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications

AM Strubberg, BB Madison - Disease models & …, 2017 - journals.biologists.com
MicroRNAs (miRNAs) are small single-stranded RNAs that repress mRNA translation and
trigger mRNA degradation. Of the∼ 1900 miRNA-encoding genes present in the human …

Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives

A Díaz-López, G Moreno-Bueno… - Cancer management and …, 2014 - Taylor & Francis
The microRNAs (miRNAs) are a class of small, 20–22 nucleotides in length, endogenously
expressed noncoding RNAs that regulate multiple targets posttranscriptionally. Interestingly …