The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic
reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear …

Cancer represents a leading cause of death worldwide. Hence, a better understanding of
the molecular mechanisms causing and propelling the disease is of utmost importance …

Abstract Calcium (Ca 2+) is a secondary messenger that regulates various cellular
processes. However, Ca 2+ mishandling could lead to pathological conditions. Orai1 is a Ca …

The endomembrane system consists of organellar membranes in the biosynthetic pathway
[endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the …

Inherited arrhythmias are the leading causes for cardiac arrest and sudden cardiac death
(SCD). Other than ion channel mutations, inherited arrhythmias including catecholaminergic …

Abstract Store-operated Ca2+ entry (SOCE) is a major pathway for calcium signaling, which
regulates almost every biological process, involving cell proliferation, differentiation …

Cytosolic calcium (Ca2+) transients control key neural processes, including neurogenesis,
migration, the polarization and growth of neurons, and the establishment and maintenance …

Abstract Store-operated Ca 2+ entry (SOCE) is an ancient and ubiquitous Ca 2+ signaling
pathway that is present in virtually every cell type. Over the last two decades, many studies …

Osteoporosis, a systemic skeletal disorder marked by diminished bone mass and
compromised bone microarchitecture, is becoming increasingly prevalent due to an aging …

This investigation aims to elucidate the novel role of Stromal Interaction Molecule 1 (STIM1)
in modulating store-operated calcium entry (SOCE) and its subsequent impact on …