Network biology concepts in complex disease comorbidities
The co-occurrence of diseases can inform the underlying network biology of shared and
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …
Integrative approaches for finding modular structure in biological networks
A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …
the cell. To this end, large and complex networks of molecular interactions are being rapidly …
[HTML][HTML] Evidence for network evolution in an Arabidopsis interactome map
Arabidopsis Interactome Mapping … - Science (New York …, 2011 - ncbi.nlm.nih.gov
Plants have unique features that evolved in response to their environments and ecosystems.
A full account of the complex cellular networks that underlie plant-specific functions is still …
A full account of the complex cellular networks that underlie plant-specific functions is still …
Evolution and functional cross‐talk of protein post‐translational modifications
Protein post‐translational modifications (PTM s) allow the cell to regulate protein activity and
play a crucial role in the response to changes in external conditions or internal states …
play a crucial role in the response to changes in external conditions or internal states …
[HTML][HTML] Features of the biochemistry of Mycobacterium smegmatis, as a possible model for Mycobacterium tuberculosis
J Ranjitha, A Rajan, V Shankar - Journal of infection and public health, 2020 - Elsevier
An alternate host for mycobacteria is Mycobacterium smegmatis which is used frequently. It
is a directly budding eco-friendly organism not emulated as human infection. It is mainly …
is a directly budding eco-friendly organism not emulated as human infection. It is mainly …
Evolution of resilience in protein interactomes across the tree of life
Phenotype robustness to environmental fluctuations is a common biological phenomenon.
Although most phenotypes involve multiple proteins that interact with each other, the basic …
Although most phenotypes involve multiple proteins that interact with each other, the basic …
Network context and selection in the evolution to enzyme specificity
Enzymes are thought to have evolved highly specific catalytic activities from promiscuous
ancestral proteins. By analyzing a genome-scale model of Escherichia coli metabolism, we …
ancestral proteins. By analyzing a genome-scale model of Escherichia coli metabolism, we …
Microbial laboratory evolution in the era of genome‐scale science
Laboratory evolution studies provide fundamental biological insight through direct
observation of the evolution process. They not only enable testing of evolutionary theory and …
observation of the evolution process. They not only enable testing of evolutionary theory and …
Evidence for Network Evolution in an Arabidopsis Interactome Map
Arabidopsis Interactome Mapping Consortium… - Science, 2011 - science.org
Plants have unique features that evolved in response to their environments and ecosystems.
A full account of the complex cellular networks that underlie plant-specific functions is still …
A full account of the complex cellular networks that underlie plant-specific functions is still …
An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors
Transcription factors (TFs) play key roles in both development and stress responses. By
integrating into and rewiring original systems, novel TFs contribute significantly to the …
integrating into and rewiring original systems, novel TFs contribute significantly to the …