Elevated levels of neutrophil activated proteins, alpha-defensins (DEFA1), calprotectin (S100A8/A9) and myeloperoxidase (MPO) are associated with disease severity …
S Shrivastava, S Chelluboina, P Jedge… - Frontiers in Cellular …, 2021 - frontiersin.org
Understanding of the basis for severity and fatal outcome of SARS-CoV-2 infection is of
paramount importance for developing therapeutic options and identification of prognostic …
paramount importance for developing therapeutic options and identification of prognostic …
A multi-omics longitudinal study reveals alteration of the leukocyte activation pathway in COVID-19 patients
Severe coronavirus disease 2019 (COVID-19) infection may lead to lung injury, multi-organ
failure, and eventually death. Cytokine storm due to excess cytokine production has been …
failure, and eventually death. Cytokine storm due to excess cytokine production has been …
Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement …
Most patients infected with SARS-CoV-2 display mild symptoms with good prognosis, while
20% of patients suffer from severe viral pneumonia and up to 5% may require intensive care …
20% of patients suffer from severe viral pneumonia and up to 5% may require intensive care …
A novel 3-gene signature for identifying COVID-19 patients based on bioinformatics and machine learning
G Lai, H Liu, J Deng, K Li, B Xie - Genes, 2022 - mdpi.com
Although many biomarkers associated with coronavirus disease 2019 (COVID-19) were
found, a novel signature relevant to immune cells has not been developed. In this work, the …
found, a novel signature relevant to immune cells has not been developed. In this work, the …
Proteomics research of SARS-CoV-2 and COVID-19 disease
N Zhang, S Wang, CCL Wong - Medical Review, 2022 - degruyter.com
Abstract Currently, coronavirus disease 2019 (COVID-19) is still spreading in a global scale,
exerting a massive health and socioeconomic crisis. Deep insights into the molecular …
exerting a massive health and socioeconomic crisis. Deep insights into the molecular …
Common molecular signatures between coronavirus infection and Alzheimer's disease reveal targets for drug development
Background: Cognitive decline is a common consequence of COVID-19, and studies
suggest a link between COVID-19 and Alzheimer's disease (AD). However, the molecular …
suggest a link between COVID-19 and Alzheimer's disease (AD). However, the molecular …
Noninvasive nasopharyngeal proteomics of COVID-19 patient identify abnormalities related to complement and coagulation cascade and mucosal immune system
MA Ayass, W Cao, J Zhang, J Dai, K Zhu, T Tripathi… - Plos one, 2022 - journals.plos.org
Serum or plasma have been the primary focus of proteomics studies for COVID-19 to identity
biomarkers and potential drug targets. The nasal mucosal environment which consists of …
biomarkers and potential drug targets. The nasal mucosal environment which consists of …
Proteomics advances towards developing SARS-CoV-2 therapeutics using in silico drug repurposing approaches
Standing amidst the COVID-19 pandemic, we have faced major medical and economic crisis
in recent times which remains to be an unresolved issue till date. Although the scientific …
in recent times which remains to be an unresolved issue till date. Although the scientific …
Buffy coat transcriptomic analysis reveals alterations in host cell protein synthesis and cell cycle in severe COVID-19 patients
LTF Cavalcante, GC da Fonseca… - International Journal of …, 2022 - mdpi.com
Transcriptome studies have reported the dysregulation of cell cycle-related genes and the
global inhibition of host mRNA translation in COVID-19 cases. However, the key genes and …
global inhibition of host mRNA translation in COVID-19 cases. However, the key genes and …
Detection of mutant peptides of SARS-CoV-2 variants by LC/MS in the DDA approach using an in-house database
Equipped with a dramatically high mutation rate, which happens to be a signature of RNA
viruses, SARS-CoV-2 trampled across the globe infecting individuals of all ages and …
viruses, SARS-CoV-2 trampled across the globe infecting individuals of all ages and …