Chronic headache is particularly prevalent in migraineurs and it can progress to a condition
known as medication overuse headache (MOH). MOH is a secondary headache caused by …

Adolescence is an evolutionarily conserved developmental period, with neural circuits and
behaviors contributing to the detection, procurement, and receipt of rewards bearing …

In this review, we will discuss the safety of repeated treatments with ketamine for patients
with treatment-resistant depression (TRD), a condition in which patients with major …

Alcohol use disorder needs more effective treatments because relapse rates remain high.
Psychedelics, such as ayahuasca, have been used to treat substance use disorders. Our …

Previous research from our laboratory has shown that exposure to chronic psychosocial
stress increased voluntary ethanol consumption and preference as well as acquisition of …

Clinical evidence suggests superior antidepressant response over time with a repeated,
intermittent ketamine treatment regimen as compared to a single infusion. However, the club …

The orthosteric γ-aminobutyric acid B (GABA B) receptor agonist baclofen is currently
considered a therapeutic option for alcohol use disorder (AUD); however, the safety profile …

Alcohol use disorders include drinking problems that span a range from binge drinking to
alcohol abuse and dependence. Plastic changes in synaptic efficacy, such as long-term …

Animal models have suggested that prenatal ethanol exposure (PEE) alters the κ opioid
receptor system. The present study investigated the brain expression of dynorphin and …

This study analyzed ethanol intake in male and female Wistar rats exposed to maternal
separation (MS) during infancy (postnatal days 1–21, PD1–21) and environmental …