Protein kinase C (PKC) is a family of Ser/Thr kinases that regulate a multitude of cellular
processes through participation in the phosphoinositide signaling pathway. Significant …

The recent discovery and structure determination of a novel ubiquitin‐like dimerization
domain in protein kinase D (PKD) has significant implications for its activation. PKD is a …

Optimal tuning of enzyme signaling is critical for cellular homeostasis. We use fluorescence
resonance energy transfer reporters in live cells to follow conformational transitions that tune …

The 1, 4-α-glucan branching enzyme (GBE, EC 2.4. 1.18) catalyzes the formation of α-1, 6
branching points in starch and plays a key role in synthesis. To obtain mechanistic insights …

Bryostatin 1 (henceforth bryostatin) is in clinical trials for the treatment of Alzheimer's disease
and for HIV/AIDS eradication. It is also a preclinical lead for cancer immunotherapy and …

Protein kinase C-α (PKCα) has been studied widely as a paradigm for conventional PKCs,
with two C1 domains (C1A and C1B) being important for the regulation and function of the …

Diacylglycerol (DAG) is a versatile lipid whose 1, 2-sn-stereoisomer serves both as second
messenger in signal transduction pathways that control vital cellular processes, and as …

Protein kinase C (PKC) modulators are currently of great importance in preclinical and
clinical studies directed at cancer, immunotherapy, HIV eradication, and Alzheimer's …

The C1 domain represents the recognition module for diacylglycerol and phorbol esters in
protein kinase C, Ras guanine nucleotide releasing protein (RasGRP), and related proteins …

Abstract Protein Kinase C isoenzymes (PKCs) are the key mediators of the phosphoinositide
signaling pathway, which involves regulated hydrolysis of phosphatidylinositol (4, 5) …