Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …

Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

Although alternative splicing (AS) drives transcriptional responses and cellular adaptation to
environmental stresses, its contributions in organ transplantation have not been …

Insulin receptor (IR) signaling defects cause a variety of metabolic diseases including
diabetes. Moreover, inherited mutations of the IR cause severe insulin resistance, leading to …

Kidney function in metabolism is often underestimated. Although the word “clearance” is
associated to “degradation”, at nephron level, proper balance between what is truly …

Insulin controls glucose homeostasis and cell growth through bifurcated signaling pathways.
Dysregulation of insulin signaling is linked to diabetes and cancer. The spindle checkpoint …

Hyperinsulinemia is the hallmark of insulin resistance in obesity, and the relative importance
of insulin clearance, insulin resistance, and insulin hypersecretion has been widely debated …

Hepatic and systemic insulin resistance form the core of metabolic syndrome which is also
associated with cardiovascular abnormalities, inflammation, and dyslipidemia. Skeletal …

The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in
insulin clearance remains poorly understood. OBJECTIVE: This study aimed to clarify …

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a
transmembrane glycoprotein that is expressed on epithelial, endothelial and immune cells …