Pulmonary vascular remodelling is an important pathological feature of pulmonary
hypertension, leading to increased pulmonary vascular resistance and reduced compliance …

Chronic pulmonary hypertension is a serious complication of a number of chronic lung and
heart diseases. In addition to vasoconstriction, its pathogenesis includes injury to the …

Background Pulmonary hypertension (PH) is a devastating disease with poor prognosis and
high mortality. Hypoxia induced pulmonary hypertension (HPH) is a persistent threat to …

Chronic hypoxia induces pulmonary hypertension and right ventricular (RV) hypertrophy.
Nitric oxide (NO) has been proposed to modulate the pulmonary vascular response to …

Nitric oxide (NO) is a potent vasodilator and inhibitor of vascular remodeling. Reduced NO
production has been implicated in the pathophysiology of pulmonary hypertension, with …

We examined whether overproduction of endogenous nitric oxide (NO) can prevent hypoxia-
induced pulmonary hypertension and vascular remodeling by using endothelial NO …

The mechanism of acute hypoxic pulmonary vasoconstriction (HPV) may involve the
inhibition of several voltage-gated K+ channels in pulmonary artery smooth muscle cells …

To examine the effect of chronic hypoxia on nitric oxide (NO) production and the amount of
the endothelial isoform of nitric oxide synthase (eNOS) in lungs of newborn piglets, studies …

Prolonged exposure to alveolar hypoxia induces physiological changes in the pulmonary
vasculature that result in the development of pulmonary hypertension. A hallmark of hypoxic …

It has been shown that mice deficient in the gene coding for endothelial nitric-oxide synthase
(eNOS) have increased pulmonary arterial pressure and pulmonary vascular resistance. In …