The γ-lactam moiety is present in a large number of natural and non-natural biologically
active compounds. The range of biological activities covered by these compounds is very …

Review covering up to 07/2019 (−)-Parthenolide is a germacrane sesquiterpene lactone,
available in ample amounts from the traditional medical plant feverfew (Tanacetum …

Despite recent advancements in the development of catalytic asymmetric electrophile
induced lactonization reactions of olefinic carboxylic acids, the archetypical …

Owing to the strong nucleophilicity of the NH2 group, free‐NH2 glycinates react with MBH
acetates to usually deliver N‐allylated products even in the absence of catalysts. Without …

The reactivities of cyclic enones and α, β-unsaturated lactones were characterized by
following the kinetics of their reactions with colored carbon-centered reference nucleophiles …

A novel phosphine‐catalyzed, highly enantioselective umpolung addition of trifluoromethyl
ketimines to Morita–Baylis–Hillman carbonates was developed and it provides facile access …

Sesquiterpene lactones (SLs) are plant-derived compounds that are abundant in plants of
the Asteraceae family and posses a broad spectrum of biological activities, ranging from anti …

The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …

Nitrogen‐bearing rings are common features in the molecular structures of modern drugs,
with chiral δ‐lactams being an important subclass due to their known pharmacological …

The α‐methylene‐γ‐butyrolactone motif is a widely encountered unit in many natural
products and pharmaceutical compounds. Herein, a practical and efficient synthesis of α …