Neuropathic pain, comprising a range of heterogeneous conditions, is often severe and
difficult to manage, and this may result in a chronic condition that negatively affects the …

Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory system. It is generally chronic and challenging to treat. The recommended …

The gabapentinoid drugs gabapentin and pregabalin are key front‐line therapies for various
neuropathies of peripheral and central origin. Originally designed as analogs of GABA, the …

The focus of perioperative pain management should be to attempt to minimise the
nociceptive input and reduce the risk of transition to central sensitisation. Gabapentinoids …

Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-
2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the …

In this study we explore if loss of GABAergic inhibitory interneurons in the superficial dorsal
horn of the spinal cord contributes to reduced GABAergic tone and neuropathic pain …

Curcumin, a phenolic compound present in Curcuma longa, has been reported to exert
antinociceptive effects in some animal models, but the mechanisms remain to be elucidated …

Neuropathic pain remains poorly treated for large numbers of patients, and little progress
has been made in developing novel classes of analgesics. To redress this issue, ziconotide …

Pregabalin has demonstrated efficacy in several forms of neuropathic pain, but its long-term
efficacy in central post-stroke pain (CPSP) is unproven. We evaluated the efficacy and safety …

Pregabalin is a specific ligand of the alpha 2-delta (α 2-δ) auxiliary subunit of voltage-gated
calcium channels. A growing body of evidence from studies of anxiety and pain indicate that …