[HTML][HTML] Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in …
Adverse outcome pathways (AOPs) organize knowledge on the progression of toxicity
through levels of biological organization. By determining the linkages between toxicity …
through levels of biological organization. By determining the linkages between toxicity …
Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity
H Ellinger-Ziegelbauer, J Aubrecht, JC Kleinjans… - Toxicology letters, 2009 - Elsevier
Specific genotoxic events such as gene mutations and/or chromosome damage are
considered hallmarks of cancer. The genotoxicity testing battery enables relatively simple …
considered hallmarks of cancer. The genotoxicity testing battery enables relatively simple …
Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies
H Ellinger-Ziegelbauer, H Gmuender… - Mutation Research …, 2008 - Elsevier
The carcinogenic potential of chemicals is currently evaluated with rodent life-time
bioassays, which are time consuming, and expensive with respect to cost, number of …
bioassays, which are time consuming, and expensive with respect to cost, number of …
[图书][B] Batch effects and noise in microarray experiments: sources and solutions
A Scherer - 2009 - Wiley Online Library
High-content, high-density long or short oligonucleotide microarrays for simultaneous
measurement of redundancy of RNA species are nowadays widely used for hypothesis …
measurement of redundancy of RNA species are nowadays widely used for hypothesis …
Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium
K Oshida, N Vasani, RS Thomas, D Applegate… - PloS one, 2015 - journals.plos.org
The nuclear receptor family member peroxisome proliferator-activated receptor α (PPARα) is
activated by therapeutic hypolipidemic drugs and environmentally-relevant chemicals to …
activated by therapeutic hypolipidemic drugs and environmentally-relevant chemicals to …
Editor's highlight: Application of gene set enrichment analysis for identification of chemically induced, biologically relevant transcriptomic networks and potential …
JL Dean, QJ Zhao, JC Lambert… - Toxicological …, 2017 - academic.oup.com
The rate of new chemical development in commerce combined with a paucity of toxicity data
for legacy chemicals presents a unique challenge for human health risk assessment. There …
for legacy chemicals presents a unique challenge for human health risk assessment. There …
[图书][B] Toxicologic pathology: nonclinical safety assessment
PS Sahota, JA Popp, JF Hardisty, C Gopinath - 2013 - books.google.com
As drug development shifts over time to address unmet medical needs and more targeted
therapies are developed, previously unseen pharmacological or off-target effects may occur …
therapies are developed, previously unseen pharmacological or off-target effects may occur …
Impact of genomics platform and statistical filtering on transcriptional benchmark doses (BMD) and multiple approaches for selection of chemical point of departure …
AF Webster, N Chepelev, R Gagné, B Kuo, L Recio… - PloS one, 2015 - journals.plos.org
Many regulatory agencies are exploring ways to integrate toxicogenomic data into their
chemical risk assessments. The major challenge lies in determining how to distill the …
chemical risk assessments. The major challenge lies in determining how to distill the …
The enhanced value of combining conventional and “omics” analyses in early assessment of drug-induced hepatobiliary injury
H Ellinger-Ziegelbauer, M Adler, A Amberg… - Toxicology and applied …, 2011 - Elsevier
The InnoMed PredTox consortium was formed to evaluate whether conventional preclinical
safety assessment can be significantly enhanced by incorporation of molecular profiling …
safety assessment can be significantly enhanced by incorporation of molecular profiling …
Application of genomic biomarkers to predict increased lung tumor incidence in 2-year rodent cancer bioassays
RS Thomas, L Pluta, L Yang… - Toxicological sciences, 2007 - academic.oup.com
Rodent cancer bioassays are part of a legacy of safety testing that has not changed
significantly over the past 30 years. The bioassays are expensive, time consuming, and use …
significantly over the past 30 years. The bioassays are expensive, time consuming, and use …