The ability of one enzyme to catalyse multiple, mechanistically distinct transformations likely
played a crucial role in organisms' abilities to adapt to changing external stimuli in the past …

Conspectus The biotechnological revolution has made it possible to create enzymes for
many reactions by directed evolution. However, because of the immense number of …

In proteins, the amino acids Phe, Tyr, and especially Trp are frequently involved in π
interactions such as π–π, cation− π, and CH− π bonds. These interactions are often crucial …

The Friedel–Crafts (F–C) reaction has been a fundamental pillar of both academic and
industrial synthetic organic chemistry since its discovery in 1873. Its success is based on the …

An artificial heme enzyme was created through self‐assembly from hemin and the
lactococcal multidrug resistance regulator (LmrR). The crystal structure shows the heme …

Supramolecular anchoring of transition metal complexes to a protein scaffold is an attractive
approach to the construction of artificial metalloenzymes since this is conveniently achieved …

We report the supramolecular assembly of artificial metalloenzymes (ArMs), based on the
Lactococcal multidrug resistance regulator (LmrR) and an exogeneous copper (II) …

How enzymes achieve their enormous rate enhancements remains a central question in
biology, and our understanding to date has impacted drug development, influenced enzyme …

The last five years have witnessed major developments in the understanding of the allosteric
phenomenon, broadly defined as coupling between remote molecular sites. Such advances …

Allosteric transcription factor (aTF) biosensors are valuable tools for engineering microbes
toward a multitude of applications in metabolic engineering, biotechnology, and synthetic …