Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Tumor heterogeneity plays a key role in prostate cancer prognosis, therapy selection,
relapse, and acquisition of treatment resistance. Prostate cancer presents a heterogeneous …

Purpose: Advances in prostate cancer lag behind other tumor types partly due to the paucity
of models reflecting key milestones in prostate cancer progression. Therefore, we develop …

ABSTRACT P53 is a critical tumor suppressor gene, activating p53 and its downstream
targets to induce apoptosis is a promising way for cancer therapy. However, more than 50 …

Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk.
However, whether pro-oxidants protect from PC remained unclear. In this work, we show that …

Increased adiposity confers risk for systemic insulin resistance and type 2 diabetes (T2D),
but mechanisms underlying this pathogenic inter-organ crosstalk are incompletely …

Oncogenic activation of MYC in cancers predominantly involves increased transcription
rather than coding region mutations. However, MYC-dependent lymphomas frequently …

Pinin (PNN), a desmosome associated protein, was demonstrated to be over-expressed and
act as a tumor-promoting factor in ovarian cancer, hepatocellular carcinoma and colorectal …

Many multiple sclerosis (MS)-associated common risk variants as well as candidate low-
frequency and rare variants have been identified; however, approximately half of MS …

Objective: A decrease in nitric oxide, leading to vascular smooth muscle cell proliferation, is
a common pathological feature of vascular proliferative diseases. Nitric oxide synthesis by …