The neuronal cell adhesion and recognition molecule L1 does not only 'keep cells
together'by way of homophilic and heterophilic interactions, but can also promote cell …

Mammalian brain circuits are wired by dynamic formation and remodeling during
development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation …

Background Cancer stem cells (CSC) have been implicated in tumor progression. In ovarian
carcinoma (OC), CSC drive tumor formation, dissemination and recurrence, as well as drug …

Deposition of amyloid-β (Aβ) in the brain is one of the important histopathological features of
Alzheimer's disease (AD). Previously, we reported a correlation between cell adhesion …

Novel technologies such as single-cell RNA and single-nucleus RNA sequencing have
shed new light on the complexity of different microglia populations in physiological and …

Introduction Stem cell therapy using neural progenitor cells (NPCs) shows promise in
mitigating the debilitating effects of spinal cord injury (SCI). Notably, myelin stimulates …

The important functions of cell adhesion molecule L1 in the nervous system depend on
diverse proteolytic enzymes which generate different L1 fragments. It has been reported that …

Adhesion molecules regulate cell proliferation, migration, survival, neuritogenesis, synapse
formation and synaptic plasticity during the nervous system's development and in the adult …

Alzheimer's disease (AD) is characterized by deposition of β-amyloid protein (Aβ),
neurofibrillary tangles and cognitive deficits resulting from neuronal cell death. In search for …

Abnormal functions of the cell adhesion molecule L1 are linked to several neural diseases.
Proteolytic L1 fragments were reported to interact with nuclear and mitochondrial proteins to …