A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Endothelial cells line blood vessels and provide a dynamic interface between the blood and
tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during …

Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of the
Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in …

Background Dexamethasone improves the survival of COVID-19 patients in need of
supplemental oxygen therapy. Although its broad immunosuppressive effects are well …

cAMP is a universal second messenger that plays central roles in cardiovascular regulation
influencing gene expression, cell morphology, and function. A crucial step toward a better …

Epithelial apico-basal polarity is established through the asymmetric cortical distribution of
the Par, Crumbs and Scribble polarity modules. Apical (Par and Crumbs) and basolateral …

The Rho subfamily members of Rho GTPases, RhoA, RhoB, and RhoC, are key regulators
of signal transduction in a variety of cellular processes, including regulation of actomyosin …

Endothelial cells lining blood vessels regulate vascular barrier function, which controls the
passage of plasma proteins and circulating cells across the endothelium. In most normal …

Endothelial cell–cell adherens junctions (AJs) supervise fundamental vascular functions,
such as the control of permeability and transmigration of circulating leukocytes, and the …

Abstract Background The Hippo pathway is widely considered to inhibit cell growth and play
an important role in regulating the size of organs. However, recent studies have shown that …