Antibodies are highly potent therapeutic scaffolds with more than a hundred different
products approved on the market. Successful development of antibody-based drugs …

Broad conformational ensembles make intrinsically disordered proteins or regions
entropically intriguing. Although methodologically challenging and understudied, emerging …

Deposition of amyloid plaques in the brains of Alzheimer's disease (AD) patients is a
hallmark of the disease. AD plaques consist primarily of the beta-amyloid (Aβ) peptide but …

The pathological aggregation of α-synuclein (αS) into amyloid fibrils is the hallmark of
Parkinson's disease (PD). The self-assembly and membrane interactions of αS are mainly …

Protein homeostasis collapse typically leads to protein aggregation into amyloid fibrils and
diffuse amorphous aggregates, which both occur in Alzheimer's and other …

Many neurodegenerative diseases, including Alzheimer's, originate from the conversion of
proteins into pathogenic conformations. The microtubule-associated protein tau converts …

Altered protein folding leading to the formation of structured aggregates such as amyloid
fibrils has gained significant attention due to its association with neurodegenerative …

ATP-independent molecular chaperones are important for maintaining cellular fitness but
the molecular determinants for preventing aggregation of partly unfolded protein substrates …

Antibody profiling is a fundamental component of understanding the humoral response in a
wide range of disease areas. Most currently used approaches operate by capturing …

Neurodegenerative diseases (NDs) are aging-related diseases that involve the death of
neurons in the brain. Dysregulation of protein homeostasis leads to the production of toxic …