Simple Summary Some regions of aggressive malignancies experience hypoxia due to
inadequate blood supply. Cancer cells adapting to hypoxic conditions somehow become …

It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

Background NCAPD3 is one of the three non-SMC subunits of condensin II complex, which
plays an important role in the chromosome condensation and segregation during mitosis …

Oxygen, which is necessary for sustaining energy metabolism, is consumed in many
biochemical reactions in eukaryotes. When the oxygen supply is insufficient for maintaining …

The lack of neuroprotective treatments for retinal ganglion cells (RGCs) and optic nerve (ON)
is a central challenge for glaucoma management. Emerging evidence suggests that redox …

Hypoxia is a common feature in various pathophysiological contexts, including tumor
microenvironment, and IFN-γ is instrumental for anti-tumor immunity. HIF1α has long been …

Abstract Background In 1957, Francis Crick drew a linear diagram on a blackboard. This
diagram is often called the “central dogma.” Subsequently, the relationships between …

The term 'magic bullet'is a scientific concept proposed by the German Nobel laureate Paul
Ehrlich in 1907, describing a medicine that could specifically and efficiently target a disease …

Branched-chain amino acids (BCAAs) provide nutrient signals for cell survival and growth.
How BCAAs affect CD8+ T cell functions remains unexplored. Herein, we report that …

This article reviews the dynamic interactions of the tumour microenvironment, highlighting
the roles of acetyl-CoA and melatonergic pathway regulation in determining the interactions …