Biological hypotheses, risk factors, and biomarkers of schizophrenia

Z Fišar - Progress in Neuro-Psychopharmacology and …, 2023 - Elsevier
Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …

[HTML][HTML] The insula: Leveraging cellular and systems-level research to better understand its roles in health and schizophrenia

AR Kittleson, ND Woodward, S Heckers… - … & Biobehavioral Reviews, 2024 - Elsevier
Schizophrenia is a highly heterogeneous disorder characterized by a multitude of complex
and seemingly non-overlapping symptoms. The insular cortex has gained increasing …

[HTML][HTML] Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

K Brosch, F Stein, S Schmitt, JK Pfarr… - Molecular …, 2022 - nature.com
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum
disorder (SSD, schizophrenia, and schizoaffective disorder) overlap in symptomatology, risk …

Clinical anatomy of the precuneus and pathogenesis of the schizophrenia

A Messina, G Cuccì, C Crescimanno… - Anatomical Science …, 2023 - Springer
Recent evidence has shown that the precuneus plays a role in the pathogenesis of
schizophrenia. The precuneus is a structure of the parietal lobe's medial and posterior …

Gross anatomical variations of the insular cortex in first-episode schizophrenia

T Takahashi, D Sasabayashi, Y Takayanagi… - Schizophrenia …, 2023 - Elsevier
Background Magnetic resonance imaging (MRI) studies have revealed gray matter
reductions in the insular cortex of schizophrenia patients. Despite large inter-individual …

[HTML][HTML] Imprecise predictive coding is at the core of classical schizophrenia

PF Liddle, EB Liddle - Frontiers in Human Neuroscience, 2022 - frontiersin.org
Current diagnostic criteria for schizophrenia place emphasis on delusions and
hallucinations, whereas the classical descriptions of schizophrenia by Kraepelin and Bleuler …

Cannabidiol attenuates insular activity during motivational salience processing in patients with early psychosis

B Gunasekera, R Wilson, A O'Neill… - Psychological …, 2023 - cambridge.org
BackgroundThe mechanisms underlying the antipsychotic potential of cannabidiol (CBD)
remain unclear but growing evidence indicates that dysfunction in the insula, a key brain …

Association between internet addiction, brain structure, and social capital in adolescents

M Matsunaga, Y Ohtsubo, K Ishii, H Tsuboi… - Social …, 2023 - Taylor & Francis
Of late, internet addiction among adolescents has become a serious problem, with
increased internet use. Previous research suggests that the more people become addicted …

[HTML][HTML] Are Neurodevelopmental Structural Pathologies of the Insula Potential Biomarkers for Schizophrenia Risk?

S Gebhardt, HA Nasrallah - Biomarkers in Neuropsychiatry, 2024 - Elsevier
The insula is a significant neural region associated with the development and clinical
symptoms of schizophrenia. Here, we provide an overview of the role of the insula in a non …

[HTML][HTML] Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?

A Sfera - Reports, 2023 - mdpi.com
In 1957, Arvid Carlsson discovered that dopamine, at the time believed to be nothing more
than a norepinephrine precursor, was a brain neurotransmitter in and of itself. By 1963 …