Diabetic wound-healing science

JL Burgess, WA Wyant, B Abdo Abujamra, RS Kirsner… - Medicina, 2021 - mdpi.com
Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by
prolonged hyperglycemia that leads to long-term health consequences. It is estimated that …

The skin microbiome: current landscape and future opportunities

P Smythe, HN Wilkinson - International journal of molecular sciences, 2023 - mdpi.com
Our skin is the largest organ of the body, serving as an important barrier against the harsh
extrinsic environment. Alongside preventing desiccation, chemical damage and …

The role and mechanism of butyrate in the prevention and treatment of diabetic kidney disease

X Cheng, T Zhou, Y He, Y Xie, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Diabetic kidney disease (DKD) remains the leading cause of the end-stage renal disease
and is a major burden on the healthcare system. The current understanding of the …

Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding

M Blumer, T Brown, MB Freitas, AL Destro… - Science …, 2022 - science.org
Vampire bats are the only mammals that feed exclusively on blood. To uncover genomic
changes associated with this dietary adaptation, we generated a haplotype-resolved …

Antimicrobial proteins: structure, molecular action, and therapeutic potential

M Hassan, TW Flanagan, N Kharouf, C Bertsch… - Pharmaceutics, 2022 - mdpi.com
Second-and third-line treatments of patients with antibiotic-resistant infections can have
serious side effects, such as organ failure with prolonged care and recovery. As clinical …

Cutaneous changes in diabetic patients: primed for aberrant healing?

VY Chen, LG Siegfried, M Tomic‐Canic… - Wound Repair and …, 2023 - Wiley Online Library
Cutaneous manifestations affect most patients with diabetes mellitus, clinically presenting
with numerous dermatologic diseases from xerosis to diabetic foot ulcers (DFUs). Skin …

Antimicrobial Peptides for Diabetic Wound Healing: Preclinical and Clinical Studies

A Herman, AP Herman - Advances in Wound Care, 2023 - liebertpub.com
The purpose of this review is to provide verified data on the current knowledge acquired
from preclinical and clinical studies regarding topically used antimicrobial peptides (AMPs) …

RNase 7 Inhibits Uropathogenic Escherichia coli-Induced Inflammation in Bladder Cells under a High-Glucose Environment by Regulating the JAK/STAT Signaling …

CH Ho, PW Liao, CK Fan, SP Liu… - International journal of …, 2022 - mdpi.com
Antimicrobial peptides (AMPs), which are natural antibiotics, protect against pathogens
invading the urinary tract. RNase 7 with antimicrobial properties has rapid and powerful …

Antimicrobial peptide derived from insulin‐like growth factor‐binding protein 5 improves diabetic wound healing

H Yue, P Song, N Sutthammikorn… - Wound Repair and …, 2022 - Wiley Online Library
Impaired keratinocyte functions are major factors that are responsible for delayed diabetic
wound healing. In addition to its antimicrobial activity, the antimicrobial peptide derived from …

Retinoic acid induces antimicrobial peptides and cytokines leading to Mycobacterium tuberculosis elimination in airway epithelial cells

YM Jacobo-Delgado, F Torres-Juarez… - Peptides, 2021 - Elsevier
Tuberculosis (TB) is the leading cause of death by a single infectious agent, Mycobacterium
tuberculosis (Mtb). Alveolar macrophages and respiratory epithelial cells are the first cells …