The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer's disease: a new perspective

NH Ali, HM Al-Kuraishy, AI Al-Gareeb… - Acta Neurologica …, 2024 - Springer
Alzheimer's disease (AD) is the most common type of dementia associated with amyloid
beta (Aβ) deposition. Dysfunction of the neuronal clearance pathway promotes the …

Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease

MZ Bin Ibrahim, Z Wang… - Philosophical …, 2024 - royalsocietypublishing.org
The synaptic tagging and capture (STC) hypothesis lays the framework on the synapse-
specific mechanism of protein synthesis-dependent long-term plasticity upon synaptic …

Inhibition of VDAC1 Rescues Aβ1-42‐Induced Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK and Wnt/β‐Catenin Pathways

X Zhou, X Tang, T Li, D Li, Z Gong… - Mediators of …, 2023 - Wiley Online Library
Beta‐amyloid (Aβ) accumulation in the brains of Alzheimer's disease (AD) patients leads to
mitochondrial dysfunction and ferroptosis in neurons. Voltage‐dependent anion channel 1 …

Discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of APP/PS1 and MAPT× P301S transgenic mice at the early stage of …

Q Wang, C Xia, A Zhu, Y Bao, J Lu, Y Chen, J Xu… - Metabolic Brain …, 2023 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder, and is caused
by multiple pathological factors, such as the overproduction of β-amyloid (Aβ) and the …

Tetramethylpyrazine ameliorates systemic streptozotocin-induced Alzheimer-like pathology

C Deng, Z Meng, H Chen, S Meng - Journal of Chemical Neuroanatomy, 2023 - Elsevier
Diabetes mellitus (DM) and its complications are the main threats to the global disease
burden. DM-related cognitive dysfunction is a progressive neurodegenerative disease …

Lateral olfactory tract usher substance (LOTUS), an endogenous Nogo receptor antagonist, ameliorates disease progression in amyotrophic lateral sclerosis model …

T Ikeda, K Takahashi, M Higashi, H Komiya… - Cell Death …, 2023 - nature.com
Abstract Nogo–Nogo receptor 1 (NgR1) signaling is significantly implicated in
neurodegeneration in amyotrophic lateral sclerosis (ALS). We previously showed that lateral …

Zinc Ameliorates Nogo-a receptor and osteocalcin gene expression in memory-sensitive rat hippocampus impaired by intracerebroventricular injection of …

H Gumus, SB Baltaci, O Unal, E Gulbahce-Mutlu… - … Trace Element Research, 2023 - Springer
Metabolic dysfunction is a critical step in the etiopathogenesis of Alzheimer's disease. In this
progressive neurological disorder, impaired zinc homeostasis has a key role that needs to …

Behavioral stress and antidepressant treatments altered hippocampal expression of Nogo signal-related proteins in rats

M Nibuya, D Kezuka, Y Kanno, S Wakamatsu… - Journal of Psychiatric …, 2024 - Elsevier
Some immune molecules including neurite outgrowth inhibitor (Nogo) ligands and their
receptor (Nogo receptor-1: NgR1) are expressed at the neuronal synaptic sites. Paired …

Correlation of brain tissue volume loss with inflammatory biomarkers IL1β, P-tau, T-tau, and NLPR3 in the aging cognitively impaired population

KM Lee, ST Kim, Y Tian, SM Jung, Y Chang… - Frontiers in Aging …, 2024 - frontiersin.org
Background Blood inflammatory biomarkers have emerged as important tools for
diagnosing, assessing treatment responses, and predicting neurodegenerative diseases …

Nogo‐A‐mediated constraints on activity‐dependent synaptic plasticity and associativity in rat hippocampal CA2 synapses

MV Pavon, S Navakkode, S Sajikumar - Hippocampus, 2024 - Wiley Online Library
Hippocampal area CA2 has garnered attention in recent times owing to its significant
involvement in social memory and distinctive plasticity characteristics. Research has …