Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …

Depression is a complex, heterogeneous disorder and a leading contributor to the global
burden of disease. Most previous research has focused on individual brain regions and …

Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and
altered immune signaling. It is unclear whether these altered immunological states have a …

Understanding the transcriptional changes that are engaged in stress resilience may reveal
novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing …

Schizophrenia is one of the leading causes of disability among mental disorders,
contributing to a substantial socioeconomic burden. Our understanding of the mechanisms …

The molecular mechanisms underlying multi-brain region origins and sexual dimorphism of
anxiety remain unclear. Here, we leverage large-scale transcriptomics from seven brain …

Background The placenta is the principal organ regulating intrauterine growth and
development, performing critical functions on behalf of the developing fetus. The delineation …

ALS is a rapidly progressive, devastating neurodegenerative illness of adults that produces
disabling weakness and spasticity arising from death of lower and upper motor neurons. No …

Background Diabetic nephropathy (DN) is the major complication of diabetes mellitus, and
leading cause of end-stage renal disease. The underlying molecular mechanism of DN is …

Besides playing a central role in neuroinflammation, microglia regulate synaptic
development and is involved in plasticity. Converging lines of evidence suggest that these …