Gliomas are primary brain tumours that are thought to derive from neuroglial stem or
progenitor cells. On the basis of their histological appearance, they have been traditionally …

In theory, in vitro and in vivo models for human gliomas have great potential to not only
enhance our understanding of glioma biology, but also to facilitate the development of novel …

Patient-based cancer models are essential tools for studying tumor biology and for the
assessment of drug responses in a translational context. We report the establishment a large …

The most frequently mutated metabolic genes in human cancer are those encoding the
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …

Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the
large majority of diffuse gliomas and are associated with hypermethylation of DNA and …

Purpose: Isocitrate dehydrogenase (IDH) gene mutations occur in low-grade and high-grade
gliomas. We sought to identify the genetic basis of malignant phenotype heterogeneity in …

Despite advances in understanding of the molecular pathogenesis of glioma, outcomes
remain dismal. Developing successful treatments for glioma requires faithful in vivo disease …

Many patients with glioma harbor specific mutations in the isocitrate dehydrogenase gene
IDH1 that associate with a relatively better prognosis. IDH1-mutated tumors produce the …

IDH1 mutations in gliomas associate with longer survival. Prooxidant and antiproliferative
effects of IDH1 mutations and its d-2-hydroxyglutarate (2-HG) product have been described …

Simple Summary Preclinical models are essential for the advancement of our understanding
of glioma biology and the development of novel therapeutics. Much of our progress in the …