Mechanisms underlying spindle assembly and robustness
The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …
Following more than a century of study, many components and pathways contributing to …
Microtubule-organizing centers
J Wu, A Akhmanova - Annual review of cell and developmental …, 2017 - annualreviews.org
The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …
during cell division, for positioning and transport of different organelles, and for cell polarity …
Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2
The microtubules that comprise mitotic spindles in animal cells are nucleated at
centrosomes and by spindle assembly factors that are activated in the vicinity of chromatin …
centrosomes and by spindle assembly factors that are activated in the vicinity of chromatin …
Mechanisms of mitotic spindle assembly
S Petry - Annual review of biochemistry, 2016 - annualreviews.org
Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …
Meiotic spindle assembly and chromosome segregation in oocytes
I Bennabi, ME Terret, MH Verlhac - Journal of Cell Biology, 2016 - rupress.org
Oocytes accumulate maternal stores (proteins, mRNAs, metabolites, etc.) during their growth
in the ovary to support development after fertilization. To preserve this cytoplasmic maternal …
in the ovary to support development after fertilization. To preserve this cytoplasmic maternal …
XMAP215 is a microtubule nucleation factor that functions synergistically with the γ-tubulin ring complex
How microtubules (MTs) are generated in the cell is a major question in understanding how
the cytoskeleton is assembled. For several decades, γ-tubulin has been accepted as the …
the cytoskeleton is assembled. For several decades, γ-tubulin has been accepted as the …
Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
C Sánchez-Huertas, F Freixo, R Viais, C Lacasa… - Nature …, 2016 - nature.com
Neurons display a highly polarized microtubule network that mediates trafficking throughout
the extensive cytoplasm and is crucial for neuronal differentiation and function. In newborn …
the extensive cytoplasm and is crucial for neuronal differentiation and function. In newborn …
α-tubulin tail modifications regulate microtubule stability through selective effector recruitment, not changes in intrinsic polymer dynamics
J Chen, E Kholina, A Szyk, VA Fedorov, I Kovalenko… - Developmental cell, 2021 - cell.com
Microtubules are non-covalent polymers of αβ-tubulin dimers. Posttranslational processing
of the intrinsically disordered C-terminal α-tubulin tail produces detyrosinated and Δ2 …
of the intrinsically disordered C-terminal α-tubulin tail produces detyrosinated and Δ2 …
A hydrodynamic instability drives protein droplet formation on microtubules to nucleate branches
Liquid–liquid phase separation, occurs not only in bulk liquid, but also on surfaces. In
physiology, the nature and function of condensates on cellular structures remain …
physiology, the nature and function of condensates on cellular structures remain …
Molecular architecture of the augmin complex
Accurate segregation of chromosomes during mitosis depends on the correct assembly of
the mitotic spindle, a bipolar structure composed mainly of microtubules. The augmin …
the mitotic spindle, a bipolar structure composed mainly of microtubules. The augmin …