Alternative splicing and related RNA binding proteins in human health and disease

Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Targeting splicing factors for cancer therapy

A Bashari, Z Siegfried, R Karni - RNA, 2023 - rnajournal.cshlp.org
Alternative splicing (AS) of mRNAs is an essential regulatory mechanism in eukaryotic gene
expression. AS misregulation, caused by either dysregulation or mutation of splicing factors …

Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity”

A Sattler, T Korzun, K Gupta, P Diba… - Cancer and Metastasis …, 2025 - Springer
Nerve signaling within the tumor microenvironment (TME) plays a critical role in the
initiation, progression, and metastasis of solid tumors. Due to their highly responsive …

Food toxicity of mycotoxin citrinin and molecular mechanisms of its potential toxicity effects through the implicated targets predicted by computer-aided …

S Zargar, TA Wani - Life, 2023 - mdpi.com
The mycotoxin citrinin, which can contaminate food, is a major global concern. Citrinin is
regarded as an inevitable pollutant in foods and feed since fungi are widely present in the …

Alternative splicing changes promoted by NOVA2 upregulation in endothelial cells and relevance for gastric cancer

A Di Matteo, E Belloni, D Pradella… - International journal of …, 2023 - mdpi.com
Angiogenesis is crucial for cancer progression. While several anti-angiogenic drugs are in
use for cancer treatment, their clinical benefits are unsatisfactory. Thus, a deeper …

Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2

SH Kim, KD Nichols, EN Anderson, Y Liu, N Ramesh… - Elife, 2023 - elifesciences.org
Mutations in the ubiquitin (Ub) chaperone Ubiquilin 2 (UBQLN2) cause X-linked forms of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) through unknown …

Identification of EMT-related alternative splicing event of TMC7 to promote invasion and migration of pancreatic cancer

Y Weng, H Qian, L Hong, S Zhao, X Deng… - Frontiers in …, 2023 - frontiersin.org
Objective Epithelial-to-mesenchymal transition (EMT) is tightly associated with the invasion
and metastasis of pancreatic cancer with rapid progression and poor prognosis. Notably …

Evaluation of the antitumoral effects of the mesoionic compound MI-D: Implications for endothelial cells viability and angiogenesis inhibition

RF de Oliveira, IR Stoltz, PG Gonçalves… - Chemico-biological …, 2024 - Elsevier
Angiogenesis is considered one of the hallmarks of cancer, assisting tumor progression and
metastasis. The mesoionic compound, MI-D, can induce cell death and provoke cytoskeletal …

[HTML][HTML] Aurora kinase A regulates cancer-associated RNA aberrant splicing in breast cancer

S Li, Y Qi, J Yu, Y Hao, L Xu, X Ding, M Zhang, J Geng - Heliyon, 2023 - cell.com
The contribution of oncogenes to tumor-associated RNA splicing and the relevant molecular
mechanisms therein require further elaboration. Here, we show that oncogenic Aurora …

Challenges in Therapeutically Targeting the RNA‐Recognition Motif

S Schmeing, P Hart - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
The RNA recognition motif (RRM) is the most common RNA binding domain found in the
human proteome. RRM domains provide RNA‐binding proteins with sequence specific RNA …