Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate

L Bonello, US Tantry, R Marcucci, R Blindt… - Journal of the American …, 2010 - jacc.org
The addition of clopidogrel to aspirin treatment reduces ischemic events in a wide range of
patients with cardiovascular disease. However, recurrent ischemic event occurrence during …

Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives

DJ Angiolillo, A Fernandez-Ortiz, E Bernardo… - Journal of the American …, 2007 - jacc.org
Antiplatelet therapy is the cornerstone of treatment for patients with acute coronary
syndromes and/or undergoing percutaneous coronary interventions. Clopidogrel, in …

Standard-vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial

MJ Price, PB Berger, PS Teirstein, JF Tanguay… - Jama, 2011 - jamanetwork.com
Context High platelet reactivity while receiving clopidogrel has been linked to cardiovascular
events after percutaneous coronary intervention (PCI), but a treatment strategy for this issue …

Reduction in ischemic events with ticagrelor in diabetic patients with prior myocardial infarction in PEGASUS–TIMI 54

DL Bhatt, MP Bonaca, S Bansilal, DJ Angiolillo… - Journal of the American …, 2016 - jacc.org
Background: Patients with diabetes appear to be at elevated risk of atherothrombotic events.
Objectives: The purpose of this study was to determine the effect of antiplatelet therapy with …

Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic …

SD Wiviott, E Braunwald, DJ Angiolillo, S Meisel… - Circulation, 2008 - Am Heart Assoc
Background—Patients with diabetes mellitus (DM) are at high risk for recurrent
cardiovascular events after acute coronary syndromes, in part because of increased platelet …

Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial

S James, DJ Angiolillo, JH Cornel… - European heart …, 2010 - academic.oup.com
Aims Patients with diabetes mellitus (DM) have high platelet reactivity and are at increased
risk of ischaemic events and bleeding post-acute coronary syndromes (ACS). In the …

Mean platelet volume in type 2 diabetes mellitus

TA Kodiatte, UK Manikyam, SB Rao… - Journal of laboratory …, 2012 - thieme-connect.com
Context: diabetes mellitus is a global pandemic. The increased platelet activity may play a
role in the development of vascular complications of this metabolic disorder. The mean …

Antiplatelet therapies for the treatment of cardiovascular disease

AD Michelson - Nature Reviews Drug Discovery, 2010 - nature.com
Antiplatelet therapy has been successful in reducing mortality and morbidity in acute
myocardial infarction. Recent advances in understanding the molecular basis of the role of …

Diabetes and antiplatelet therapy in acute coronary syndrome

JL Ferreiro, DJ Angiolillo - Circulation, 2011 - Am Heart Assoc
Cardiovascular disease, particularly coronary artery dis-ease resulting from accelerated
atherosclerosis, is the leading cause of morbidity and mortality in patients with diabetes …

Clinical pharmacokinetics and pharmacodynamics of clopidogrel

XL Jiang, S Samant, LJ Lesko, S Schmidt - Clinical pharmacokinetics, 2015 - Springer
Acute coronary syndromes (ACS) remain life-threatening disorders, which are associated
with high morbidity and mortality. Dual antiplatelet therapy with aspirin and clopidogrel has …