Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

Large-scale whole-genome sequencing studies have enabled analysis of noncoding rare-
variant (RV) associations with complex human diseases and traits. Variant-set analysis is a …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

Diabetic kidney disease (DKD) is a severe diabetic complication that affects up to half of the
individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD …

Genome-wide association studies have discovered hundreds of associations between
common genotypes and kidney function but cannot comprehensively investigate rare coding …

Human large-scale genetic association studies have identified sequence variations at
thousands of genetic risk loci that are more common in patients with diverse metabolic …

Chronic kidney disease (CKD) is a complex disorder that causes a gradual loss of kidney
function, affecting approximately 9.1% of the world's population. Here, we use a soft …

Admixed populations arise when two or more ancestral populations interbreed. As a result of
this admixture, the genome of admixed populations is defined by tracts of variable size …

Principal component analysis (PCA) is widely used to control for population structure in
genome-wide association studies (GWAS). Top principal components (PCs) typically reflect …