Reverse engineering human brain evolution using organoid models

MA Mostajo-Radji, MT Schmitz, ST Montoya, AA Pollen - Brain research, 2020 - Elsevier
Primate brains vary dramatically in size and organization, but the genetic and
developmental basis for these differences has been difficult to study due to lack of …

Endoderm and mesoderm derivatives in embryonic stem cell differentiation and their use in developmental toxicity testing

RH Mennen, MM Oldenburger, AH Piersma - Reproductive Toxicology, 2022 - Elsevier
Embryonic stem cell differentiation models have increasingly been applied in non-animal
test systems for developmental toxicity. After the initial focus on cardiac differentiation …

Sidestream smoke extracts from harm-reduction and conventional Camel cigarettes inhibit osteogenic differentiation via oxidative stress and differential activation of …

NRL Sparks, LM Walker, SR Sera, JV Madrid, M Hanna… - Antioxidants, 2022 - mdpi.com
Epidemiological studies suggest cigarette smoking as a probable environmental factor for a
variety of congenital anomalies, including low bone mass, increased fracture risk and poor …

An evaluation of human induced pluripotent stem cells to test for cardiac developmental toxicity

LM Walker, NRL Sparks, V Puig-Sanvicens… - International Journal of …, 2021 - mdpi.com
To prevent congenital defects arising from maternal exposure, safety regulations require pre-
market developmental toxicity screens for industrial chemicals and pharmaceuticals …

Fine particulate matter reduces the pluripotency and proliferation of human embryonic stem cells through ROS induced AKT and ERK signaling pathway

S Bi, J Tang, L Zhang, L Huang, J Chen, Z Wang… - Reproductive …, 2020 - Elsevier
Epidemiological investigations have found that air fine particulate matter (PM) exposure not
only causes respiratory and cardiovascular diseases in adults and children, but also affects …

Perturbations in Osteogenic Cell Fate Following Exposure to Constituents Present in Tobacco: A Combinatorial Study

JV Madrid, MKM Vera-Colón, NI Zur Nieden - Toxics, 2023 - mdpi.com
Tobacco smoke contains between 7000 and 10,000 constituents, and only an evanescently
low number of which have been identified, let alone been evaluated for their toxicity …

Video-based kinetic analysis of calcification in live osteogenic human embryonic stem cell cultures reveals the developmentally toxic effect of Snus tobacco extract

IKC Martinez, NRL Sparks, JV Madrid… - Toxicology and applied …, 2019 - Elsevier
Epidemiological studies suggest tobacco consumption as a probable environmental factor
for a variety of congenital anomalies, including low bone mass and increased fracture risk …

Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration

MA Garland, S Sengupta, LK Mathew, L Truong… - Toxicology Reports, 2019 - Elsevier
We previously used a chemical genetics approach with the larval zebrafish to identify small
molecule inhibitors of tissue regeneration. This led to the discovery that glucocorticoids (GC) …

[PDF][PDF] The utilization of embryonic stem cells to discern embryotoxicity in vitro

M Kavuri - 2022 - escholarship.org
The terms developmental toxicity and embryotoxicity are becoming prominent in today's
research, drawing attention to the harmful toxicants pregnant women are exposed to on a …

Risk Assessment Using Human Pluripotent Stem Cells: Recent Advances in Developmental Toxicity Screens

KK Buck, NI zur Nieden - Stem Cells in Birth Defects Research …, 2018 - books.google.com
Chemical exposure may potentially affect embryonic developmental structures and their
function. Since toxic agents can be found within everyday workplaces, houses, and natural …