Polyethylenimine (PEI) has recently been widely studied for the design of nucleic acid
delivery vehicles. Gene delivery using PEI involves condensation of DNA into compact …

The discovery of RNA interference (RNAi) as a naturally occurring mechanism for gene
knockdown has attracted considerable attention toward the use of small interfering RNAs …

Gene therapy has emerged as an alternative for the treatment of diseases refractory to
conventional therapeutics. Synthetic nanoparticle-based gene delivery systems offer highly …

SARS-CoV-2 has been the cause of a global pandemic since 2019 and remains a medical
urgency. siRNA-based therapies are a promising strategy to fight viral infections. By …

Pulmonary drug and gene delivery to the lung represents a non-invasive avenue for local
and systemic therapies. However, the respiratory tract provides substantial barriers that …

Despite major progress in both therapeutic and diagnostic techniques, lung cancer is still
considered the leading cause of cancer mortality in the world due to the ineffectiveness of …

As a nascent and emerging field that holds great potential for precision oncology,
nanotechnology has been envisioned to improve drug delivery and imaging capabilities …

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the
fabrication of most dosage forms, irrespective of the administration route. They play various …

Small interfering RNA (siRNA) that silence genes by the process of RNA interference offers
a new therapeutic modality for disease treatment. Polycation-based nanoparticles termed …

Inhalation is the main pathway of ZnO exposure in the occupational environment but only
few studies have addressed toxic effects after pulmonary exposure to ZnO nanoparticles …