A comprehensive overview of coumarinyl-triazole hybrids as anticancer agents

AR Nesaragi, JS Algethami, M Alsaiari… - Journal of Molecular …, 2024 - Elsevier
There are over 100 commercially available drugs for the handling of cancer, but only a
handful of them have high specificity, leading to a variety of side effects. The past few …

Structural Modification Strategies of Triazoles in Anticancer Drug Development

Q Guan, Z Gao, Y Chen, C Guo, Y Chen… - European Journal of …, 2024 - Elsevier
The triazole functional group plays a pivotal role in the composition of biomolecules with
potent anticancer activities, including numerous clinically approved drugs. The strategic …

New Coumarin− Thiosemicarbazone Based Zn (II), Ni (II) and Co (II) Metal Complexes: Investigation of Cholinesterase, α‐Amylase, and α‐Glucosidase Enzyme …

E Çelik, M Özdemir, B Köksoy, T Taskin‐Tok… - …, 2023 - Wiley Online Library
New coumarin− thiosemicarbazone compounds and their zinc (II), nickel (II), and copper (II)
metal complexes were synthesized and characterized. The inhibitory activities of these new …

Recent Progress in the Synthesis and Biological Assessment of Benzimidazole-1, 2, 3-Triazole Hybrids

DK Singh, H Iqbal, MA Ansari - Current Organic Chemistry, 2024 - benthamdirect.com
In recent times, many research groups have focused their attention on nitrogencontaining
heterocyclic compounds with the aim of gaining a deeper understanding of their biological …

Therapeutic potential of 1, 2, 3‐triazole hybrids for leukemia treatment

W Yang, B Xuan, X Li, H Si, A Chen - Archiv der Pharmazie, 2022 - Wiley Online Library
Leukemia, a hematological malignancy originating from the bone marrow, is the principal
cancer of childhood. In recent decades, improved remission rates and survival of patients …

The anti‐breast cancer therapeutic potential of 1, 2, 3‐triazole‐containing hybrids

J Song, S Zhang, B Zhang, J Ma - Archiv der Pharmazie, 2024 - Wiley Online Library
Breast cancer, as one of the most common invasive malignancies and the leading cause of
cancer‐related deaths in women globally, poses a significant challenge in the world health …

Discovery of novel tris-1, 2, 3-triazole-based hybrids as VEGFR2 inhibitors with potent anti-proliferative and cytotoxicity through apoptosis induction

M Alsehli, AAS Ali, MS Nafie, S Bardaweel… - Bioorganic …, 2025 - Elsevier
The discovery of novel anti-cancer drugs motivated us to synthesize a new series of triple 1,
2, 3-triazole-based arm scaffolds featuring distinct un/functionalized alkyl and/or aryl side …

[HTML][HTML] Photocurable biomaterials labeled with luminescent sensors dedicated to bioprinting

P Jamróz, A Świeży, M Noworyta, K Starzak… - Journal of …, 2024 - Elsevier
In the present study, we focused on the development and characterization of formulations
that function as biological inks. These inks were doped with coumarin derivatives to act as …

Coumarin as an Elite Scaffold in Anti-Breast Cancer Drug Development: Design Strategies, Mechanistic Insights, and Structure–Activity Relationships

A Singh, K Singh, K Kaur, A Singh, A Sharma, K Kaur… - Biomedicines, 2024 - mdpi.com
Breast cancer is the most common cancer among women. Currently, it poses a significant
threat to the healthcare system due to the emerging resistance and toxicity of available drug …

The current landscape of coumarin hybrids with antibreast cancer therapeutic applications: An updated review

R Wang, Z Chen, Y Huang, Q Zhang… - Archiv der …, 2024 - Wiley Online Library
Globally, breast cancer (BC) has the highest prevalence among malignant diseases. BC is
also the primary cause of death among women. Notably, BC morbidity has been increasing …