V Deretic, T Saitoh, S Akira - Nature Reviews Immunology, 2013 - nature.com
Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity. Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it …
WJ Kaiser, H Sridharan, C Huang, P Mandal… - Journal of Biological …, 2013 - ASBMB
Toll-like receptor (TLR) signaling is triggered by pathogen-associated molecular patterns that mediate well established cytokine-driven pathways, activating NF-κB together with …
H Guo, S Omoto, PA Harris, JN Finger, J Bertin… - Cell host & …, 2015 - cell.com
Summary Herpes simplex virus (HSV)-1 and HSV-2 are significant human pathogens causing recurrent disease. During infection, HSV modulates cell death pathways using the …
F Pietrocola, V Izzo, M Niso-Santano, E Vacchelli… - Seminars in cancer …, 2013 - Elsevier
Autophagy is an evolutionarily conserved process that promotes the lysosomal degradation of intracellular components including organelles and portions of the cytoplasm. Besides …
X Dong, B Levine - Journal of innate immunity, 2013 - karger.com
The autophagy pathway is an essential component of host defense against viral infection, orchestrating pathogen degradation (xenophagy), innate immune signaling, and certain …
R Karim, B Tummers, C Meyers, JL Biryukov… - PLoS …, 2013 - journals.plos.org
Persistent infection of basal keratinocytes with high-risk human papillomavirus (hrHPV) may cause cancer. Keratinocytes are equipped with different pattern recognition receptors …
Viruses have played an important role in human evolution and have evolved diverse strategies to co-exist with their hosts. As obligate intracellular pathogens, viruses exploit and …
S Omoto, H Guo, GR Talekar, L Roback… - Journal of biological …, 2015 - ASBMB
Necroptosis is an alternate programmed cell death pathway that is unleashed by caspase-8 compromise and mediated by receptor-interacting protein kinase 3 (RIP3). Murine …
Programmed cell death is an integral part of host defense against invading intracellular pathogens. Apoptosis, programmed necrosis, and pyroptosis each serve to limit pathogen …