The significance of D-amino acids in soil, fate and utilization by microbes and plants: review and identification of knowledge gaps
V Vranova, H Zahradnickova, D Janous, KR Skene… - Plant and soil, 2012 - Springer
Background D-amino acids are far less abundant in nature than L-amino acids. Both L-and
D-amino acids enter soil from different sources including plant, animal and microbial …
D-amino acids enter soil from different sources including plant, animal and microbial …
Kinetics of β-lactam antibiotics synthesis by penicillin G acylase (PGA) from the viewpoint of the industrial enzymatic reactor optimization
Competition with well-established, fine-tuned chemical processes is a major challenge for
the industrial implementation of the enzymatic synthesis of β-lactam antibiotics. Enzyme …
the industrial implementation of the enzymatic synthesis of β-lactam antibiotics. Enzyme …
Current state and perspectives of penicillin G acylase-based biocatalyses
H Marešová, M Plačková, M Grulich, P Kyslík - Applied microbiology and …, 2014 - Springer
In the course of more than 60-year history, penicillin G acylase (PGA) gained a unique
position among enzymes used by pharmaceutical industry for production of β-lactam …
position among enzymes used by pharmaceutical industry for production of β-lactam …
Selectivity and kinetic modeling of penicillin G acylase variants for the synthesis of cephalexin under a broad range of substrate concentrations
PR Harris, MA Grover, RW Rousseau… - Biotechnology and …, 2022 - Wiley Online Library
The kinetics of cephalexin synthesis and hydrolysis of the activated acyl‐donor precursor
phenylglycine methyl ester (PGME) were characterized under a broad range of substrate …
phenylglycine methyl ester (PGME) were characterized under a broad range of substrate …
Continuous reactive crystallization of β-lactam antibiotics catalyzed by penicillin G acylase. Part I: Model development
A model is developed for simulating continuous manufacturing of β-lactam antibiotics by
enzymatic reactive crystallization. An amoxicillin case study using the unified model of …
enzymatic reactive crystallization. An amoxicillin case study using the unified model of …
Enzymatic synthesis of amoxicillin by penicillin G acylase in the presence of ionic liquids
SC Pereira, R Bussamara, G Marin, RLC Giordano… - Green chemistry, 2012 - pubs.rsc.org
A major obstacle for the industrial implementation of the enzymatic synthesis of β-lactam
antibiotics is the limited yield of the product, due to undesirable hydrolytic reactions. This …
antibiotics is the limited yield of the product, due to undesirable hydrolytic reactions. This …
Efficient synthesis of β-lactam antibiotics with in situ product removal by a newly isolated penicillin G acylase
X Pan, A Li, Z Peng, X Ji, J Chu, B He - Bioorganic Chemistry, 2020 - Elsevier
Abstract A penicillin G acylase (PGA) from Achromobacter xylosoxidans PX02 was newly
isolated, and site-directed mutagenesis at three important positions αR141, αF142, βF24 …
isolated, and site-directed mutagenesis at three important positions αR141, αF142, βF24 …
Strategies to improve the biosynthesis of β-lactam antibiotics by penicillin G acylase: Progress and prospects
X Pan, L Xu, Y Li, S Wu, Y Wu, W Wei - Frontiers in Bioengineering …, 2022 - frontiersin.org
β-Lactam antibiotics are widely used anti-infection drugs that are traditionally synthesized
via a chemical process. In recent years, with the growing demand for green alternatives …
via a chemical process. In recent years, with the growing demand for green alternatives …
Synthesis and antimicrobial activities of new higher amino acid Schiff base derivatives of 6-aminopenicillanic acid and 7-aminocephalosporanic acid
Ö Özdemir, P Gürkan, B Özçelik, Ö Oyardı - Journal of Molecular Structure, 2016 - Elsevier
Novel β-lactam derivatives (1c-3c)(1d-3d) were produced by using 6-aminopenicillanic acid
(6-APA), 7-aminocephalosporanic acid (7-ACA) and the higher amino acid Schiff bases. The …
(6-APA), 7-aminocephalosporanic acid (7-ACA) and the higher amino acid Schiff bases. The …
Penicillin G acylase from Achromobacter sp. CCM 4824: An efficient biocatalyst for syntheses of beta-lactam antibiotics under conditions employed in large-scale …
S Bečka, V Štěpánek, RW Vyasarayani… - Applied microbiology …, 2014 - Springer
Penicillin G acylase from Achromobacter sp.(NPGA) was studied in the enzymatic synthesis
of β-lactam antibiotics by kinetically controlled N-acylation. When compared with penicillin …
of β-lactam antibiotics by kinetically controlled N-acylation. When compared with penicillin …