Consistent with the concept of the gut-brain phenomenon, observational studies suggest a
relationship between Alzheimer's disease (AD) and gastrointestinal tract (GIT) disorders; …

Background The question of whether asthma is causally related to gastrointestinal disorders
remained unanswered so far. Thus, this study investigated whether there is such a relation …

Background Gastro-oesophageal reflux disease (GORD) is associated with idiopathic
pulmonary fibrosis (IPF) in observational studies. It is not known if this association arises …

Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly
associated with immune-mediated disorders. In this study, we implemented multitrait joint …

Background Observational studies have shown an association between gastroesophageal
reflux disease (GERD) and anxiety disorders/depression. However, these evidences may be …

Aim A recent study has reported that anti-reflux surgery reduced the risk of lung cancer.
However, the exact causal association between gastro-esophageal reflux disease (GORD) …

Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a high burden of
both pulmonary and extrapulmonary comorbidities. Research Question Do these …

Observational studies have reported that gastroesophageal reflux disease (GERD) is a risk
factor for cardiovascular diseases (CVD); however, the causal inferences between them …

Background: An association between gastro-esophageal reflux disease (GERD) and
common psychiatric conditions, most notably anxiety and depression, has been reported …

Background Numerous observational studies have identified a linkage between the gut
microbiota and gastroesophageal reflux disease (GERD). However, a clear causative …