Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …

Drug development suffers from a lack of predictive and human-relevant in vitro models.
Organ-on-chip (OOC) technology provides advanced culture capabilities to generate …

Tight junctions (TJs) are composed of a claudin-based anastomosing network of TJ strands
at which plasma membranes of adjacent epithelial cells are closely attached to regulate the …

Rapid non-invasive kidney-specific readouts are essential to maximizing the potential of
microfluidic tissue culture platforms for drug-induced nephrotoxicity screening …

The functional and structural concept of tight junctions has developed after discovery of
claudin and TAMP proteins. Many of these proteins contribute to epi-and endothelial barrier …

Tight-junction-regulated actomyosin activity determines epithelial and endothelial tension on
adherens junctions and drives morphogenetic processes; however, whether or not tight …

Disruption of the intestinal epithelial barrier is a hallmark of mucosal inflammation. It
increases exposure of the immune system to luminal microbes, triggering a perpetuating …

Tight junctions (TJ) are cell–cell adhesive structures that define the permeability of barrier-
forming epithelia and endothelia. In contrast to this seemingly static function, TJs display a …

Tight and adherens junctions are specialized sites of cell-cell interaction in epithelia and
endothelia, and are involved in barrier, adhesion, and signaling functions. These functions …