Challenges in natural product-based drug discovery assisted with in silico-based methods

CV Simoben, SB Babiaka, AFA Moumbock… - Rsc Advances, 2023 - pubs.rsc.org
The application of traditional medicine by humans for the treatment of ailments as well as
improving the quality of life far outdates recorded history. To date, a significant percentage of …

Are we ready to fight the Nipah virus pandemic? An overview of drug targets, current medications, and potential leads

S Yang, S Kar - Structural Chemistry, 2023 - Springer
Nipah virus (NiV) is a high-lethality RNA virus from the family of Paramyxoviridae and genus
Henipavirus, classified under Biosafety Level-4 (BSL-4) pathogen due to the severity of …

In silico identification of anti-SARS-CoV-2 medicinal plants using cheminformatics and machine learning

J Liang, Y Zheng, X Tong, N Yang, S Dai - Molecules, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of
COVID-19, is spreading rapidly and has caused hundreds of millions of infections and …

[HTML][HTML] Targeting non-structural proteins of Hepatitis C virus for predicting repurposed drugs using QSAR and machine learning approaches

S Kamboj, A Rajput, A Rastogi, A Thakur… - Computational and …, 2022 - Elsevier
Hepatitis C virus (HCV) infection causes viral hepatitis leading to hepatocellular carcinoma.
Despite the clinical use of direct-acting antivirals (DAAs) still there is treatment failure in 5 …

Drug repurposing for type 2 diabetes using combined textual and structural graph representation based on transformer

S Mam, D Wichadakul, P Vateekul - IEEE Access, 2023 - ieeexplore.ieee.org
Type 2 diabetes has been predominant for years. There is still no cure to help patients
completely recover from the sickness. Drug repurposing can help to discover a new drug by …

Indirect-acting pan-antivirals vs. respiratory viruses: A fresh perspective on computational multi-target drug discovery

VV Kleandrova, MT Scotti… - Current Topics in …, 2021 - ingentaconnect.com
Respiratory viruses continue to afflict mankind. Among them, pathogens such as
coronaviruses [including the current pandemic agent known as severe acute respiratory …

Drug Repurposing: A Leading Strategy for New Threats and Targets

AS Mishra, M Vasanthan… - ACS Pharmacology & …, 2024 - ACS Publications
Less than 6% of rare illnesses have an appropriate treatment option. Repurposed
medications for new indications are a cost-effective and time-saving strategy that results in …

Precision medicine for pandemics: stratification of COVID-19 molecular phenotypes defined by topological analysis of global blood gene expression.

R Penrice-Randal, F Strazzeri, B Ernst, B Van Eeckhout… - medRxiv, 2024 - medrxiv.org
Precision medicine offers a promising avenue for better therapeutic responses to pandemics
such as COVID-19. This study leverages independent patient cohorts in Florence and Liège …

[PDF][PDF] Recent Advancement and Novel Approaches of Nipah Virus: An Overview

S Dhananjay, R Kumari, R Kumar - Indian Journal of Pharmacy Practice, 2025 - ijopp.org
ABSTRACT Since the Nipah Virus (NiV) first appeared in Malaysia and Singapore in 1998-
99, the NiV virus has reappeared several times, infecting people critically and having a high …

Targeted Computational Approaches to Identify Potential Inhibitors for Nipah Virus

S Gautam, M Kumar - Current Trends in Computational Modeling for Drug …, 2023 - Springer
Nipah virus (NiV) is a bat-borne, highly pathogenic RNA virus belonging to the family
Paramyxoviridae. It is known for causing lethal encephalitis in humans with a high fatality …