The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs)
were first elucidated in 1994, and by 2001, substantial progress had been made in …

Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed,
protein-serine/threonine kinases, which participate in signal transduction pathways that …

The molecular details of mammalian stress-activated signal transduction pathways have
only begun to be dissected. This, despite the fact that the impact of these pathways on the …

Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

Nearly all cell surface receptors utilize one or more of the mitogen-activated protein kinase
cascades in their repertoire of signal transduction mechanisms. Recent advances in the …

UV irradiation acts as a broad activator of cell surface growth factor and cytokine receptors.
This ligand-independent receptor activation induces multiple downstream signaling …

Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

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c-Jun N-terminal kinases (JNKs), also referred to as stress-activated kinases (SAPKs), were
initially characterized by their activation in response to cell stress such as UV irradiation …

▪ Abstract The mitogen-activated protein kinase (MAPK) group of serine/threonine protein
kinases mediates the response of cells to many extracellular stimuli such as cytokines and …