Mutations in the CACNA1A gene that encodes the pore-forming α 1 subunit of human
voltage-gated Ca V 2.1 (P/Q-type) Ca 2+ channels cause several autosomal-dominant …

The cerebellum is important for motor coordination, as well as motor learning and memories.
Learning is believed to occur in the cerebellar cortex, in the form of synaptic plasticity …

The rate and temporal pattern of neural spiking each have the potential to influence
computation. In the cerebellum, it has been hypothesized that the irregularity of interspike …

Cerebellar climbing fiber activity encodes performance errors during many motor learning
tasks, but the role of these error signals in learning has been controversial. We compared …

Extracellular recordings were made from vestibular–nerve afferents innervating the
semicircular canals in anesthetized C57BL/6 mice ranging in age from 4–24 weeks. A …

Spinocerebellar Ataxia Type 6 (SCA6) is a mid-life onset neurodegenerative disease
characterized by progressive ataxia, dysarthria, and eye movement impairment. This …

The learning of motor skills is thought to occur largely through trial and error; however, the
error signals and rules controlling the induction of motor learning have not been fully …

The Cacna1a gene encodes the α 1A subunit of voltage-gated Ca V 2.1 Ca 2+ channels that
are involved in neurotransmission at central synapses. Ca V 2.1-α 1-knockout (α1KO) mice …

Masao Ito proposed a cerebellar learning hypothesis with Marr and Albus in the early 1970s.
He suggested that cerebellar flocculus (FL) Purkinje cells (PCs), which directly inhibit the …

Adaptive processes within cerebellar circuits, such as long-term depression and long-term
potentiation at parallel fiber-Purkinje cell synapses, have long been seen as important to …